------------------------------------- Core Groups ------------------------------------- Group 1: Glyoxylase related proteins ------------------------------------- ------------------------------------- Glyoxylase family (A,B,E) S)-(2-HYDROXYACYL)GLUTATHIONE + H(2)O = GLUTATHIONE + A 2-HYDROXY ACID ANION HP0813_Hp_2313945 YCBL_Ec_1787158 YqgX_Bs_1731031 AF0575_Af_2650049 AF1747_Af_2648803 C33A12.7_Ce_2647995 GLO2_Ec_1786406 YCBL_Ec_1074886 slr1259_Ssp_1652935 YybB_Bs_586832 YflN_Bs_2443236 AF2410_Af_2650685 GLO4_Sc_2494852 GLO2_Hi_1073883 sll1019_Ssp_1651961 GLO2_Sc_2494851 PksB_Bs_2634080 Glo2_At_1924921 c06001_Sso_1707680 GLO2_Hs_2494849 ------------------------------------- Flavin binding domain containing family (A,B) MJ0534_Mj_2826294 MJ0732_Mj_2496115 MTH1350_Mta_2622457 sll0219_Ssp_1651801 AF1519_Af_2649041 MJ0748_Mj_2496117 MTH220_Mta_2621267 AF0167_Af_2650474 sll0219_Ssp_1651801 U29579_Ec_1789064 MTH157_Mta_2621199 sll0217_Ssp_1651803 sll1521_Ssp_1653555 U96487_Dsul_2104729 ORFU_Rc_976255 ------------------------------------- Hal family (A,B) H0539_Hsp_282232 H0571_Hsp_2822327 YrkH_Bs_1731127 ------------------------------------- ------------------------------------- ------------------------------------- Group 2: RNA cleaving and DNA repair enzymes ------------------------------------- ------------------------------------- MG139 family (A,B) HP1430_Hp_2829454 MTV002.17c_Mtu_2624274 YkqC_Bs_2833392 slr0551_Ssp_1723172 MG139_Mg_1723112 MJ0861_Mj_2128073 YmfA_Bs_2634050 MTH49_Mta_2621085 MG423_Mg_1351578* ------------------------------------- CPSF family (B,A,E) MJ0047_Mj_2495763 MJ0162_Mj_2495836 AF0532_Af_2650088 sll0514_Ssp_2496795 MJ1236_Mj_2496166 (Has KH domain) MTH1203_Mta_2622312 (Has KH domain) YLR277c_Sc_1077401 AF0482_Af_2650146 (Has KH domain) F09G2.4_Ce_2435621* CPSF_Bt_1707412 PHAA034_Ph_2696478 (Has KH domain) CPSB_Bt_1706103* YLR115w_Sc_2131782* ------------------------------------- SNM family (E) SNM1_Sc_267010 Snm1_At_1495267 ha36115_Hs_77303 F39H2.1_Ce_1667320 ------------------------------------- ------------------------------------- ------------------------------------- Group 3 ------------------------------------- ------------------------------------- ELAC family (A,B) (X-SULFATE + H(2)O = X-OH + SULFATE) YqjK_Bs_1731073 slr0050_Ssp_2500943 YPGA_Pgi_1296970 (Glycosulfatase) TREP3H1 CH3H1 MTH1831_Mta_2622965 AF0939_Af_2649658 pqqG_Mex_1073172 ELAC_Ec_1788603 BB0755_Bb_2688688 MJ1502_Mj_2500945 ARS_Aca_114226 (Aryl sulfatase) MTCY253.13c_Mtu_1655652 ------------------------------------- YK59 family (E) Duplication of the YK59_Sc_549637 E04A4.4_Ce_2702418 YATA_Sp_1723232 SPBC3D6.03c_Sp_2117299 ------------------------------------- PHNP family (A,B) AF0478_Af_2650153 PHNP_Ec_1790530 BB0533_Bb_2650153 CH3H2 ------------------------------------- PHNPoid family (B) sll1036_Ssp_2494855 TREP3H2 Y09898_Cvi_2117299 ------------------------------------- ------------------------------------- ------------------------------------- Group 4: The ß-lactamase like group ------------------------------------- ------------------------------------- Dehydrase family (A,B) AF0090_Af_2650558 Deh_Scoel_282554 MTCY10D7.35c_Mt_1524223 ------------------------------------- ß-Lactamase (B) BLA2_Bsp_115023 BLA2_Bfra_115030 BLA_Aver_2292739 ------------------------------------- ------------------------------------- ------------------------------------- Group 5 (Roma/MJ1163) ------------------------------------- ------------------------------------- Roma family (B,E) YPL103c_Sc_2132980 romA_Eclo_227029 CY31.34_Mtu_1731397 ------------------------------------- MJ1163 family(A,B) YtkL_Bs_2293245 AF1264_Af_2649231 AF2152_Af_2648361 MTH1902_Mta_2623035 MJ1163_Mj_2128705 c04023_Sso_1707795 ------------------------------------- ------------------------------------- ------------------------------------- Yycj family(B) YycJ_Bs_1064810 CH3H3 ------------------------------------- MJ0448 family (A) MJ0448_Mj_2495991 MTH1101_Mta_2622202 ------------------------------------- CE family (E) C03F11.2_Ce_1049467 C23H3.8_Ce_1707116 F53B1.5_Ce_1072253 C25D7.5_Ce_2274873* ------------------------------------- AF1342 family (A,B) AF1342_Af_649228 AF1849_Af_2648382 ------------------------------------- GumP family (B) GumP_Xcam_2226283 CY339.09_Mtu_2496554 ------------------------------------- ------------------------------------- Unclustered members of core family ------------------------------------- BLA1_Xm_1705478 (ß-lactamase with an independent origin) YJFR_Ec_1790636 YddR_Bs_1881317 MTCY13D12.30_Mtu_1552879 MTV022.10_Mtu_2909566 MTV026.01_Mtu_2950415 C03A3.3_Ce_1369966 CY227.20_Mtu_1478231 MTV025.025c_Mtu_2960101 sll0647_Ssp_1652043 YhfI_Bs_2226242 YobT_Bs_2619046 YqjP_Bs_1731077 YtnP_Bs_2293208 MJ0301_Mj_2495901 MJ0888_Mj_2842578 MTH1267_Mta_2622381 MTH912_Mta_2622008 AF0234_Af_2650408 AF0534_Af_2650086 AF1349_Af_2649228 AF1497_Af_2649063 AF1508_Af_2649058 AF2147_Af_2648260 AF2269_Af_2648260 AF2386_Af_2650713 ------------------------------------- ------------------------------------- ------------------------------------- ------------------------------------- DISTINCT CLASSES ------------------------------------- ------------------------------------- MJ1374 class (A) MJ1374_Mj_2128819 MTH751_Mta_2621840 ------------------------------------- MJ1629 class (A) MJ1629_Mj_2128979 AF0504_Af_2650122 ------------------------------------- AF1497 Class (A) AF1497_Af_2649063 AF2269_Af_2648260 ------------------------------------- Alkyl sulfatase class (B,E) MTV025.110c_Mtu_2960186 ALKSP_Psp_77793 YOL164w_Sc_2132027 EPA_Shesp_2529414 YJCS_Ec_2367350 ------------------------------------- Rec2 family (Bacteria) ComEC_Bs_1303798 REC2_Hi_1172877 YCAI_Ec_1787142 COMA_Ng_1705994 ------------------------------------- Phosphodiesterase family (B,E) CNA1_Sc_1705954 CNA1_Sp_544049 CNA1_Vfis_476787 CN17_Dd_1352097 ------------------------------------- Separate family with 1 tuberculosis and 1 Myxococcus protein MTCY409.12c_Mtu_2224827 AF047554_Mx_2921879 ------------------------------------- ------------------------------------- Unclustered members ------------------------------------- CNAMo_Mm_1363107 (Has a N-terminal dioxygenase domain) MJ0296_Mj_2495897 AF2364_Af_2650735 sll0157_Ssp_1001449 SC7H1.08c_Scoe_2808766