| Group |
S. cerevisiae protein |
A. nidulans protein |
E-value |
| Cargo selection and tethering |
Vps45 |
Cytosolic and peripheral membrane protein |
AN6531.2 |
hypothetical protein similar to VpsB |
10-111 |
| Vps52 |
Involved in localization of actin and chitin |
AN4014.2 |
hypothetical protein |
10-54 |
| Vps53 |
Hydrophilic protein peripherally associated with the late Golgi |
AN2736.2 |
hypothetical protein |
10-52 |
| Vps54 |
Involved in vacuole biogenesis |
AN7993.2 |
hypothetical protein |
10-40 |
| Tlg2 |
tSNARE that affects a Late Golgi compartment |
AN2048.2 |
hypothetical protein |
10-36 |
| Cvt9 |
Involved in cytoplasm-to-vacuole targeting pathway and pexophagy |
AN2887.2 |
hypothetical protein |
10-12 |
| Cvt19 |
Involved in the cytoplasm-to-vacuole targeting pathway and in autophagy |
No homolog found |
| Vps51 |
Whiskey (whi) mutant; forms a tetramer with VPS52, VPS53, and VPS54 |
No homolog found |
| VFC - PtdIns 3-kinase complex |
Vps34 |
Phosphatidylinositol 3-kinase |
AN4709.2 |
hypothetical protein |
10-167 |
| Vps15 |
Myristoylated Serine/threonine protein kinase involved in vacuolar protein sorting |
AN0576.2 |
hypothetical protein |
10-144 |
| Apg6 |
Involved in vacuolar protein targeting |
No homolog found |
| Apg14 |
Involved in autophagy |
No homolog found |
| VFC - Conjugation systems |
Apg7 |
Similar to ubiquitin-activating enzymes, involved in autophagy |
AN7428.2 |
hypothetical protein |
10-95 |
| Aut2 |
Anchor protein, mediates attachment of autophagosomes to microtubules |
AN3470.2 |
hypothetical protein |
10-60 |
| Aut1 |
Involved in autophagocytosis |
AN7718.2 |
hypothetical protein |
10-51 |
| Aut7 |
Aut7p has homology to LC3, a microtubule-associated protein from rat |
AN5131.2 |
hypothetical protein similar to IDI-7 |
10-50 |
| Apg12 |
Involved in autophagy |
AN1760.2 |
hypothetical protein |
10-14 |
| Apg5 |
Involved in autophagy |
AN5174.2 |
hypothetical protein |
10-12 |
| Apg16 |
Involved in autophagy |
AN0090.2 |
hypothetical protein |
10-6 |
| Apg10 |
Involved in autophagy; protein-conjugating enzyme involved in the Apg12p-Apg5p conjugation pathway |
No homolog found |
| VFC - Regulatory machinery |
Apg1 |
Protein kinase |
AN1632.2 |
hypothetical protein |
10-109 |
| Cvt18 |
Required for cytoplasm to vacuole targeting of proaminopeptidase I and starvation induced autophagy (AUT10). Needed for pre-Meiotic Replication (NMR1) |
AN0127.2 |
hypothetical protein |
10-77 |
| Cvt13 |
Sorting NeXin |
AN3584.2 |
hypothetical protein |
10-72 |
| Cvt20 |
Involved in transport of aminopeptidase I (Lap4p) through the cytoplasm-to-vacuole targeting pathway |
AN6351.2 |
hypothetical protein |
10-48 |
| Vac8 |
An armadillo repeat-containing protein localized on the vacuolar membrane |
AN2142.2 |
hypothetical protein similar to AF465210_1 karyopherin alpha |
10-16 |
| Apg17 |
Required for activation of Apg1 protein kinase |
AN6360.2 |
hypothetical protein |
10-10 |
| Apg13 |
Involved in autophagy |
AN2076.2 |
hypothetical protein |
10-6 |
| VFC - Apg9 complex |
Apg9 |
Integral membrane protein |
AN3734.2 |
hypothetical protein |
10-110 |
| Apg2 |
Required for sporulation |
AN5491.2 |
hypothetical protein |
10-86 |
| VFC - Early Sec pathway |
Sec23 |
Cytoplasmic GTPase-activating protein |
AN0261.2 |
conserved hypothetical protein |
0 |
| Sec24 |
Vesicle coat component |
AN3720.2 |
hypothetical protein |
0 |
| Sec16 |
Vesicle coat component |
AN6615.2 |
hypothetical protein |
10-22 |
| Sec12 |
Guanine nucleotide exchange factor for Sar1p |
No homolog found |
| Docking and fusion |
Vps11 |
Peripheral vaculor membrane protein; putative Zn-finger protein |
AN2461.2 |
hypothetical protein |
10-82 |
| Vps18 |
Vacuolar membrane protein |
AN2266.2 |
hypothetical protein similar to DigA protein |
10-72 |
| Vps16 |
Vacuolar sorting protein |
AN6911.2 |
hypothetical protein |
10-53 |
| Vps33 |
Involved in vacuolar protein targeting |
AN2418.2 |
hypothetical protein similar to vacuolar sorting protein |
10-36 |
| Vps41 |
Component of vacuolar membrane protein complex |
AN4876.2 |
hypothetical protein |
10-34 |
| Mon1 |
Unknown |
AN2093.2 |
hypothetical protein |
10-34 |
| Vps39 |
Involved in vacuolar morphogenesis |
AN6720.2 |
hypothetical protein |
10-31 |
| Vti1 |
v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p |
AN1973.2 |
hypothetical protein |
10-22 |
| Vam7 |
Hydrophilic protein, heptad repeat motif |
AN4551.2 |
hypothetical protein |
10-14 |
| Vam3 |
Member of the syntaxin family of proteins; predicted C-terminal TMD |
AN4416.2 |
hypothetical protein |
10-13 |
| Sec18 |
Cytoplasmic protein involved in protein transport between ER and Golgi; ATPase |
AN3098.2 |
hypothetical protein |
10-171 |
| Ypt7 |
Gtp-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, and for fusion of endosomes to vacuoles when expressed from high copy plasmid |
AN0089.2 |
RAB7_NEUCR Probable Ras-related protein Rab7 |
10-72 |
| Sec17 |
peripheral membrane protein required for vesicular transport between ER and Golgi |
AN6267.2 |
hypothetical protein |
10-51 |
| Ccz1 |
Involved in sporulation, caffeine, calcium, and zinc sensitivity |
No homolog found |
| Vesicle breakdown |
Pep4 |
Vacuolar proteinase A |
AN2903.2 |
hypothetical protein similar to pepsinogen |
10-145 |
| Prb1 |
Vacuolar protease B |
AN0238.2 |
hypothetical protein |
10-123 |
| Aut4 |
Membrane transporter |
AN7437.2 |
hypothetical protein |
10-65 |
| Cvt17 |
Lipase, required for intravacuolar lysis of autophagic bodies |
AN5919.2 |
hypothetical protein |
10-39 |
| VFC - Vesicle Formation/Completion |