116418538847 periodontitis bacterial infection and inflammatory conditions promote the differentiation of monocytes to bone-resorbing osteoclasts 216418538847 periodontitis LPS and TNF-alpha mediate differentiation of the monocytes to osteoclast-like cells 316418538847 periodontitis highly purified monocytes, or alternatively, cells of the promyeloid cell line U937, differentiated to monocyte-like cells, cultivated in the presence of lipopolysaccharides(LPS) express osteoclast-typical proteins tartrate-resistant acid phosphate(TRAcP) and cathepsin K 416418538847 periodontitis highly purified monocytes, or alternatively, cells of the promyeloid cell line U937, differentiated to monocyte-like cells, cultivated in the presence of lipopolysaccharides(LPS) form resorption pits on calcium phosphate coated cover slips or ivory slices 516418538847 periodontitis local bacterial infections create a microenvironment that promotes the generation of bone resorbing cells 616418538847 periodontitis local bacterial infections generation of bone resorbing cells 716418538847 periodontitis generation of bone resorbing cells contribute to infection-associated osteolysis 816518533788 periodontitis propolis prevent alveolar bone loss 916618435789 periodontitis peripheral blood mononuclear cells (PBMCs) from periodontitis patients do not need priming by M-CSF to become osteoclast-like cells 1116718390996 periodontitis homologs of Tp92 which is a highly conserved surface protein of oral spirochetes (Treponema denticola, T. lecithinolyticum, T. maltophilum, and T. socranskii subsp. socranskii) stimutate various factors involved in inflammation and osteoclastogenesis, acting like interleukin-1beta(IL-1beta), tumor necrosis factor alpha, IL-6, prostaglandin E2, and matrix metalloproteinase 9, in host cells like monocytes and fibroblasts 1216818307044 periodontitis 1316918302623 periodontitis Lipopolysaccharide from gram-negative bacteria initiate the immune response/inflammatory response 1416918302623 periodontitis inhibiting p38 MAPK prior to lipopolysaccharide stimulation decrease RANKL mRNA expression 1516918302623 periodontitis lipopolysaccharide or p38 MAPK not affect osteoprotegerin mRNA expression 1616918302623 periodontitis Lipopolysaccharide-stimulated periodontal ligament cells increase osteoclast differentiation 1716918302623 periodontitis Lipopolysaccharide-stimulated periodontal ligament cells be completely blocked by osteoprotegerin and significantly decreased by inhibition of MAPK kinase3 and MAPK kinase6, upstream activators of p38 MAPK 1816918302623 periodontitis periodontal ligament cells produce membrane-bound RANKL 1916918302623 periodontitis LPS increase RANKL 2016918302623 periodontitis p38 MAPK pathway be required for lipopolysaccharide-induced membrane-bound RANKL expression 2117018261262 periodontitis in Periodontitis patients. induce significant decrease in alkaline phosphatase activity and the collagen type 1 production, as well as the nodule formation of mineralization, typical markers of differentiated osteoblasts 2217018261262 periodontitis osteoblasts from the patients be sensitive to apoptotic effect 2317018261262 periodontitis TNF-related apoptosis-inducing ligand(TRAIL) induce apoptotic effect on osteoclasts from the patients 2417018261262 periodontitis TRAIL induce apoptosis by interacting with its death receptors, (death receptor4, death receptor5) 2517018261262 periodontitis decoy TRAIL receptors modulate activity of TRAIL in apoptosis 2717018261262 periodontitis down-regulation of decoy TRAIL receptors expression in osteoblasts from Pd patients significantly increase the levels of TRAIL 2817018261262 periodontitis the increased TRAIL-mediated apoptosis of osteoblasts bring the alveolar bone loss in Pd patients 2917118240539 osteoporosis 3017218187046 periodontitis prostaglandin E2 mediate bone remodeling 3117218187046 periodontitis receptor activator of NF-kappaB ligand(RANKL) mediate bone-resorptive activity of prostaglandin E2 3217218187046 periodontitis RANKL induce osteoclast formation 3317218187046 periodontitis IL-1- and IL-6-stimulated bone resorption involve prostaglandin E2 production 3417218187046 periodontitis prostaglandin E2 promote bone formation in vitro by stimulating osteoblastic proliferation and differentiation 3517218187046 periodontitis Leukotrienes(LTs), and particularly Leukotriene B4 be implicated in bone remodeling 3617218187046 periodontitis platelet-activating factor receptor-deficient mice develop only mild osteoporosis 3717318176542 periodontitis Lipopolysaccharide stimulate bone resorption 3817318176542 periodontitis osteoblast be responsible for mouse strain-dependent osteoclastogenesis in response to Lipopolysaccharide 3917418155486 periodontitis 4017517897505 periodontitis Bisphosphonates treat a variety of osteometabolic diseases 4117517897505 periodontitis apoptotic osteoclasts stimulate differentiation and activity of the osteoblasts 4217517897505 periodontitis clodronate(non-aminobisphosphonates) stimulate differentiation and activity of the osteoblasts 4317618037875 periodontitis Bisphosphonates induce osteoclast apoptosis 4417618037875 periodontitis inhibition of osteoclast bone resorption impair bone wound healing 4517618037875 periodontitis Bisphosphonates decrease production of cytokines derived from the bone matrix 4617618037875 periodontitis decreased production of cytokines derived from the bone matrix make bone exposed to the risk of osteomyelitis and necrosis 4717618037875 periodontitis high-dose bisphosphonates treatment be associated with exposure to dental infections or oral surgical procedures 48118062121 periodontitis Lipopolysaccharide of Gram-negative bacteria, such as Actinobacillus actinomycetemcomitans initiate innate immune system 49118062121 periodontitis innate immune system result in inflammatory alveolar bone loss 50118062121 periodontitis Lipopolysaccharide activate Toll-like receptors on membrane surfaces 51118062121 periodontitis Toll-like receptors on membrane surfaces sitmulate many intracellular signaling cascades, including p38 MAPK 52118062121 periodontitis Activation ofp38 signaling mediate inflammatory cytokine expression 53118062121 periodontitis inflammatory cytokine expression contribute to osteoclastogenesis and bone loss 54118062121 periodontitis Administration of orally active p38 MAPK inhibitor SD282 block additional volumetric bone loss 55118062121 periodontitis orally active p38 MAPK inhibitor SD282 reduce IL-1beta 56118062121 periodontitis orally active p38 MAPK inhibitor SD282 reduce TNF-alpha 57118062121 periodontitis orally active p38 MAPK inhibitor SD282 reduce osteoclast formation 58118062121 periodontitis orally active p38 MAPK inhibitor SD282 reduce Lipopolysaccharide-induced inflammatory cytokine expression 59118062121 periodontitis orally active p38 MAPK inhibitor SD282 reduce osteoclastogenesis 60118062121 periodontitis orally active p38 MAPK inhibitor SD282 reduce alveolar bone loss 61118062121 periodontitis orally active p38 MAPK inhibitor SD282 arrest periodontal disease progression 62217929247 periodontitis Fish oil rich in n-3 polyunsaturated fatty acids, especially EPA and DHA protect inflammation induced bone loss in chronic inflammatory diseases like rheumatoid arthritis, periodontitis, and osteoporosis 63217929247 periodontitis RANKL mediate osteoclastogenesis 64217929247 periodontitis DHA inhibit osteoclast differentiation 65217929247 periodontitis DHA inhibit tartrate resistant acid phosphatase 66217929247 periodontitis DHA inhibit cathepsin K 67217929247 periodontitis DHA inhibit calcitonin receptor 68217929247 periodontitis DHA inhibit matrix metalloproteinase-9 expression and osteoclast-specific transcription factor 69217929247 periodontitis DHA inhibit c-fos 70217929247 periodontitis DHA inhibit osteotropic proinflammatory cytokine, TNF-alpha 71217929247 periodontitis DHA reduce activation of NF-kappaB 72217929247 periodontitis DHA reduce p38 MAPK 73217929247 periodontitis DHA alleviate RANKL induced proinflammatory cytokine production 75217929247 periodontitis DHA in alleviating RANKL induced proinflammatory cytokine production decrease osteoclast activation and bone resorption 76317890674 periodontitis Prostaglandin E2(PGE2) and PGE receptor subtypes (EPs) modulate osteoblast-mediated osteoclastogenesis 77617720858 periodontitis Secreted frizzled-related protein 1(SFRP1) modulate apoptosis 78617720858 periodontitis P. gingivalis-infected periodontal tissues in mice upregulate expression of SFRP1 than control mice 79617720858 periodontitis P. gingivalis-infection upregulate apoptosis of inflammatory cells, fibroblasts, and bone-lining cells than controls 80617720858 periodontitis inhibition of Secreted frizzled-related protein 1(SFRP1) expression reduce periodontal breakdown 81617720858 periodontitis inhibition of Secreted frizzled-related protein 1(SFRP1) expression reduce inflammatory cell infiltrate 82617720858 periodontitis inhibition of Secreted frizzled-related protein 1(SFRP1) expression reduce osteoclastogenesis 83617720858 periodontitis inhibition of Secreted frizzled-related protein 1(SFRP1) expression reduce apoptosis of inflammatory cells and fibroblasts 84717698421 periodontitis RANKL-induced osteoclast differentiation strongly upregulate nha-oc(nha-oc/NHA2) predominently in bone, as well as in the supraoccipitale bone, calvarium, mandible, and maxilla, suggesting expression in terminally differentiated osteoclasts 85717698421 periodontitis nha-oc positive cells co-expressing osteoclast markers of TRAP and cathepsin k inducenha-oc(nha-oc/NHA2) osteoclast localization in nha-oc positive cells 86817668983 periodontitis inflammatory bone diseases including periodontitis elevate levels of MIP-1alpha 87817668983 periodontitis IL-1beta and bacterial Lipopolysaccharide modulate MIP-1alpha expression 88817668983 periodontitis MIP-1alpha activate osteoclast 89817668983 periodontitis IL-1beta and Lipopolysaccharide indcuce high expression of MIP-1alpha 90817668983 periodontitis A. actinomycetemcomitans Lipopolysaccharide induce osteoclast formation 91817668983 periodontitis MIP-1alpha expression probably initiate inflammation by facilitating accumulation and activation of leukocytes 92917608585 periodontitis RANKL inhibitor osteoprotegerin(OPG) inhibit osteoclastogenesis 93917608585 periodontitis RANKL inhibitor osteoprotegerin(OPG) supress bone resorption 94917608585 periodontitis OPG-Fc, synthetic chimeric antagonists of RANKL-RANK interactions inhibit bone resorption in alveolar 951017550374 periodontitis anaerobic gram-negative bacteria cause inflammatory bone disease 961017550374 periodontitis balance between RANKL and osteoprotegerin(OPG) regulate Osteoclast differentiation 971017550374 periodontitis TLR-2 and TLR-4 be expressed in Human gingival fibroblasts (HGF) 981017550374 periodontitis Lipopolysaccharide of A. actinomycetemcomitans and P. gingivalis induce OPG expression in gingival fibroblasts (HGF) 991017550374 periodontitis whole cell extracts from A. actinomycetemcomitans and P. gingivalis induce osteoprotegerin(OPG) production by gingival fibroblasts (HGF) 1001017550374 periodontitis polymyxin B suppress osteoprotegerin(OPG) production by gingival fibroblasts (HGF) 1011017550374 periodontitis IND suppress osteoprotegerin(OPG) production in LPS-stimulated Human gingival fibroblasts (HGF) 1021017550374 periodontitis prostaglandin E2(PGE2) stimulate Human gingival fibroblasts (HGF) to produce osteoprotegerin(OPG) 1031017550374 periodontitis PGE receptor EP1 subtype agonist and PGE receptor EP2 subtype agonist increase osteoprotegerin(OPG) production by gingival fibroblasts (HGF) 1041117539727 periodontitis P. gingivalis-infection downgrowth of epithelial cells 1051117539727 periodontitis P. gingivalis-infection increase inflammation 1061117539727 periodontitis P. gingivalis-infection increase alveolar bone loss 1071117539727 periodontitis P. gingivalis-infection increase osteoclast activity 1081217539720 periodontitis RANKL mRNA be increased in chronic periodontitis tissue 1091217539720 periodontitis expression ratio of RANKL against OPG be significantly higher in periodontitis 1101217539720 periodontitis expression of RANKL, but not OPG be significantly correlated with increased numbers of P. gingivalis 1111417448041 periodontitis RANKL and OPG oppositely regulated in GCF from periodontitis patients 1121417448041 periodontitis RANKL, RANK and OPG significantly regulate osteoclast recruitment, differentiation and activation 1131417448041 periodontitis inflammation triggered by host immune response in pathogenesis of periodontitis induce periodontal biofilm microorganisms in periodontitis 1141417448041 periodontitis activation of T cell and B cell in the inflammatory infiltrate which bears abundant RANKL promote osteoclastic bone resorption 1151517335380 periodontitis induction of host-derived inflammatory cytokines initiate inflammatory bone loss 1161517335380 periodontitis A. actinomycetemcomitans Lipopolysaccharide induce severe bone loss 1171517335380 periodontitis A. actinomycetemcomitans Lipopolysaccharide increase IL-6 and IL-1beta and tumor necrosis factor-alpha 1181617321485 periodontitis osteoclast induce cathepsin-K 1191617321485 periodontitis periodontitis induce cathepsin-K 1201617321485 periodontitis periodontitis induce RANKL 1211717151781 periodontitis nicotine affect mineralized nodule formation 1221717151781 periodontitis nicotine and Lipopolysaccharide increase production of M-CSF and PGE2 by human osteoblastic Saos-2 cell 1231717151781 periodontitis increasing production of M-CSF and PGE2 by human osteoblastic Saos-2 cell stimulate formation of osteoclast-like cells 1241717151781 periodontitis Nicotine treatment cause expression of MMP-1, MMP-2, MMP-3, and MMP-13 1251717151781 periodontitis nicotine treatment enhance MMP-1 expression 1261717151781 periodontitis simultaneous treatment of D-tubocurarine and nicotine eliminate enhancement of MMP-1 by nicotine 1271717151781 periodontitis nicotine increase expression of tissue-type plasminogen activator(tPA) 1281717151781 periodontitis nicotine increase expression of alpha7 nicotine receptor 1291717151781 periodontitis nicotine increase expression of c-fos 1301717151781 periodontitis tissue-type plasminogen activator(tPA) increase bone matrix turnover 1311717151781 periodontitis MMP-1, MMP-2, MMP-3, and MMP-13 increase bone matrix turnover 1321817094790 periodontitis Lipopolysaccharide of periodontopathic bacteria stimulate osteoclast formation 1331817094790 periodontitis adiponectin act as a potent inhibitor of osteoclast formation 1341817094790 periodontitis TLR-4 ligand and RANKL stimulate osteoclast formation 1351817094790 periodontitis NF-kappaB act as an important transcription factor in osteoclast formation 1361817094790 periodontitis adiponectin inhibit TLR4-mediated NF-kappaB activity 1371817094790 periodontitis TLR4-mediated NF-kappaB activity upregulate gene expression for inducible nitric oxide synthase and production of nitric oxide 1381917041006 periodontitis Gram-negative bacteria derived Lipopolysaccharide initiate inflammatory bone loss 1391917041006 periodontitis p38 MAPK signaling be critical to inflammatory cytokine and LPS-induced cytokine expression 1401917041006 periodontitis inflammatory cytokine and LPS-induced cytokine expression contribute toward periodontal bone loss 1411917041006 periodontitis significantly fewer tartrate-resistant acid phosphatase-positiveosteoclasts and a significant decrease in IL-6, IL-1beta, and tumor necrosis factor alpha expression in p38 inhibitors-treated groups induce periodontal bone loss 1421917041006 periodontitis orally active p38 MAPK inhibitors reduce LPS-induced inflammatory cytokine production and osteoclast formation 1431917041006 periodontitis orally active p38 MAPK inhibitors protect against LPS-stimulated alveolar bone loss 1442116936272 periodontitis RANKL mediate osteoclastogenesis 1452116936272 periodontitis osteoclastogenesis induce inflammatory bone resorption 1462116936272 periodontitis soluble RANKL, but not its decoy receptor osteoprotegerin be significantly upregulated in diseased tissue homogenates from diseased gingival tissues than in healthy tissues 1472116936272 periodontitis RANKL express less than 20% in B cells and T cells of healthy gingival tissues 1482216920972 periodontitis Dendritic cell acting as an innate immune effector be critically involved in regulating T cell immunity 1492216920972 periodontitis RANKL induce monocyte/macrophage lineage that can differentiate Osteoclasts acting as bone-resorbing cells 1502216920972 periodontitis M-CSF induce osteoclastogenic potential upstream of RANKL/RANK signaling 1512216920972 periodontitis immature CD11c plus Dendritic cells(DC) act like osteoclast precursors 1522216920972 periodontitis CD11c plus Dendritic cells(DC)-derived Osteoclasts(OC) induce bone loss after adoptive transfer in vivo 1532416848983 periodontitis T cells support osteoclastogenesis 1542416848983 periodontitis overproduction of nuclear factor-kappa-B-ligand(RANKL) support osteoclastogenesis 1552416848983 periodontitis overproduction of tumor necrosis factor-alpha(TNF-alpha) support osteoclastogenesis 1562416848983 periodontitis IL-7 stimulate the production of osteoclastogenic factors by T cells 1572416848983 periodontitis IL-6 potentiate IL-7 expression 1582416848983 periodontitis interleukin-7 production by B lymphocytes affect T cell-dependent osteoclast formation 1592516827722 periodontitis lipopolysaccharide stimulate bone resorption 1602516827722 periodontitis cell culture in the presence of M-CSF and RANKL inhibit osteoclast differentiation from bone marrow mononuclear cells> by P. nigrescens Lipopolysaccharide(LPS) 1612516827722 periodontitis P. nigrescens lipopolysaccharide stimulate osteoclastogenesis in the coculture 1622516827722 periodontitis P. nigrescens lipopolysaccharide decrease OPG production 1632516827722 periodontitis P. nigrescens lipopolysaccharide increase TGF-beta secretion 1642516827722 periodontitis treatment with P. nigrescens lipopolysaccharide increase PGE2 production 1652516827722 periodontitis P. nigrescens lipopolysaccharide cause alveolar bone resorption 1662616805684 periodontitis Doxycycline inhibit alveolar bone destruction 1672616805684 periodontitis Doxycycline block matrix metalloproteinases(MMPs) 1682616805684 periodontitis An acidic microenvironment, which is formed by vacuolar-ATPase expressed in the plasma membranes of osteoclasts induce osteoclastic bone resorption 1692616805684 periodontitis a novel and specific vacuolar-ATPase inhibitors, FR202126 inhibit bone resorption 1702616805684 periodontitis Oral administration of FR202126 prevent alveolar bone loss 1712716723646 periodontitis Diabetes increase the intensity and duration of the inflammatory infiltrate 1722716723646 periodontitis type 2 diabetic group significant increase and activation of osteoclast 1732716723646 periodontitis Diabetes increase apoptosis 1742716723646 periodontitis Diabetes decrease osteoblasts 1752716723646 periodontitis Diabetes decrease periodontal ligament fibroblasts 1762816712777 periodontitis topical treatment of minocycline reduce gingivitis 1772816712777 periodontitis systemic treatment of minocycline inhibit alveolar bone loss 1793016702601 periodontitis conjugated linoleic acid (CLA) positively influence calcium and bone metabolism 1803016702601 periodontitis RANKL critically mediates osteoclastogenesis 1813016702601 periodontitis conjugated linoleic acid (CLA) suppress RANKL signaling 1823016702601 periodontitis conjugated linoleic acid (CLA) suppress osteoclastogenesis 1833016702601 periodontitis RANKL activate nuclear factor-kappaB(NF-kappaB) 1843016702601 periodontitis preexposure of the cells to conjugated linoleic acid (CLA) suppress RANKL-induced NF-kappaB activation, including phosphorylation of I-kappaB alpha, degradation of I-kappaB alpha, and nuclear translocation of p65 1853016702601 periodontitis RANKL induce osteoclastogenesis 1863016702601 periodontitis conjugated linoleic acid (CLA) inhibit RANKL-induced tumor necrosis factor-alpha production 1873016702601 periodontitis conjugated linoleic acid (CLA) inhibit osteoclast differentiation, including osteoclast-specific genes such as tartrate-resistant acid phosphatase, cathepsin K, calcitonin receptor, and matrix metalloproteinase-9 expression 1883016702601 periodontitis conjugated linoleic acid (CLA) inhibit osteoclast-specific transcription factors such as c-fos, nuclear factor of activated T-cells expression, and bone resorption pit formation 1893016702601 periodontitis conjugated linoleic acid (CLA) inhibit RANKL-induced activation of mitogen-activated protein kinase p38 1903016702601 periodontitis conjugated linoleic acid (CLA) inhibits osteoclastogenesis by modulating RANKL signaling 1913116671873 periodontitis omega-3 fatty acid prevent LPS-induced alveolar bone loss 1923216636611 periodontitis baicalin exhibit anti-bacterial effect 1933216636611 periodontitis baicalin exhibit anti-inflammatory effect 1943216636611 periodontitis baicalin exhibit analgesic effects 1953216636611 periodontitis baicalin inhibit nuclear factor-kappaB activation 1963216636611 periodontitis RANKL play an important role in osteoclastogenesis from osteoclast precursors to mature osteoclasts 1973216636611 periodontitis IL-1beta stimulate the expression of RANKL at mRNA and protein levels 1983216636611 periodontitis Baicalin suppress IL-1beta-induced RANKL production 1993216636611 periodontitis Baicalin sippress IL-1beta-induced COX-2 production 2003216636611 periodontitis baicalin suppress COX-2 expression induced by IL-1beta 2013216636611 periodontitis the suppression of COX-2 expression induced by IL-1beta inhibit RANKL mRNA expression 2023316584347 periodontitis celecoxib and omega-3 fatty acid influence bone remodeling 2033316584347 periodontitis celecoxib and omega-3 fatty acid inhibit the progression of alveolar bone resorption 2043416579696 periodontitis Bisphosphonates inhibit bone resorption 2053416579696 periodontitis monosodium olpadronate(OPD) inhibit bone loss 2063516552070 periodontitis Cimetidine is a powerful H2 receptor antagonist eliminate histamine- effects on chemotaxis, phagocytosis, and superoxide anion production by phagocytes 2073516552070 periodontitis topically active cimetidine potentially inhibit P. gingivalis-elicited periodontal inflammation 2083516552070 periodontitis cimetidine arrest and/or prevent tissue destruction 2093516552070 periodontitis systemic treatment of minocycline influence tissue destruction 2103516552070 periodontitis cimetidine decrease inflammation 2113616552059 periodontitis Injection of P. gingivalis stimulate gamma interferon 2123616552059 periodontitis Injection of P. gingivalis stimulate interleukin 6 2133616552059 periodontitis Injection of P. gingivalis stimulate macrophage inflammatory protein 2 2143616552059 periodontitis Injection of P. gingivalis stimulate monocyte chemoattractant protein 1 expression 2153616552059 periodontitis activation of the acquired immunity by P. gingivalis increase inflammatory 2163616552059 periodontitis activation of the acquired immunity by P. gingivalis increase connective tissue destruction 2173616552059 periodontitis activation of the acquired immunity by P. gingivalis increase degree of fibroblast apoptosis 2183616552059 periodontitis activation of the acquired immunity by P. gingivalis increase innate immune response 2193616552059 periodontitis activation of the acquired immunity by P. gingivalis increase osteoclastogenesis 2203716465026 periodontitis bisphosphonate inhibit alveolar bone resorption 2213716465026 periodontitis prostaglandin E2 increase alveolar bone resorption 2223816419037 periodontitis RANKL, osteoprotegerin(OPG), RANK signaling axis plays a critical role in dendritic cell function as well as bone remodeling 2233816419037 periodontitis The expression of RANKL by immune cells contribute to bone loss 2243816419037 periodontitis dendritic cell(DC) release the chromatin protein high mobility group box 1(HMGB1) 2253816419037 periodontitis HMGB1 binds to RAGE 2263816419037 periodontitis HMGB1 binding to membrane receptor for advanced glycation end products(RAGE) induce high mobility group box 1(HMGB1) release by Dendritic cells(DCs) mediating the interaction between Dendritic cells(DCs) and T-cells 2273816419037 periodontitis parathyroid hormone(PHT) regulate bone remodeling 2283816419037 periodontitis parathyroid hormone(PHT) attenuate high mobility group box 1(HMGB1) release 2293816419037 periodontitis HMGB1/RAGE signaling axis play a critical role in bone 2303916404138 periodontitis a novel vacuolar-ATPase inhibitors, FR202126 prevent alveolar bone destruction 2313916404138 periodontitis FR202126 inhibit proton transporter in plasma membrane vesicles of murine osteoclasts 2323916404138 periodontitis FR202126 inhibit vacuolar ATPase(V-ATPase) 2333916404138 periodontitis FR202126 inhibit bone resorption 2344016373400 periodontitis omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammatory signals produces Resolvins acting as a new family of bioactive product 2354016373400 periodontitis Resolvin E1(RvE1) protect from local inflammation and osteoclast- mediated bone destruction 2364016373400 periodontitis Resolvin E1(RvE1) bind human neutrophils at a site that is functionally distinct from the LX receptor 2374016373400 periodontitis topical application of Resolvin E1(RvE1) protect against inflammation 2394216297161 periodontitis periodontitis increase expression of interleukin-1 and other inflammatory mediators 2404216297161 periodontitis expression of interleukin-1 and other inflammatory mediators result in extensiveosteoclast formation and bone loss 2414216297161 periodontitis Expression of RANKL and its decoy receptor osteoprotegerin(OPG) by osteoblasts regulates osteoclast differentiation 2424216297161 periodontitis IL-1alpha stimulation in Human gingival fibroblasts (HGF) induce high mRNA expression of OPG 2434216297161 periodontitis cycloheximide(CHX) reduce in Human gingival fibroblasts (HGF), IL-1alpha-stimulated OPG mRNA expression 2444216297161 periodontitis protein kinase A(PKA) inhibitors abrogate IL-1alpha-induced osteoprotegerin(OPG) mRNA expression and osteoprotegerin(OPG) production 2454216297161 periodontitis Endogenous PGE2 enhance IL-1alpha-induced osteoprotegerin(OPG) production in Human gingival fibroblasts (HGF) 2464216297161 periodontitis IL-1 alpha augment in periodontal ligament fibroblasts (PDL), RANKL mRNA expression 2474216297161 periodontitis IL-1 alpha induce OPG mRNA expression and protein production 2484216297161 periodontitis protein kinase C(PKC) inhibitors reduce IL-1alpha-induced osteoprotegerin(OPG) production 2494216297161 periodontitis PKC activator enhance OPG production in periodontal ligament fibroblasts (PDL) 2504216297161 periodontitis IL-1alpha stimulation in Human gingival fibroblasts (HGF) enhance mRNA expression of osteoprotegerin(OPG) in Human gingival fibroblasts (HGF) 2514216297161 periodontitis PKC in periodontal ligament fibroblasts (PDL) contribute to OPG production 2524316289620 periodontitis lipopolysaccharide(LPS) from the cell wall of gram-negative bacteria cause alveolar bone destruction 2534316289620 periodontitis prostaglandin E2(PGE2) act as bone resorption factors 2544316289620 periodontitis prostaglandin E2(PGE2) stimulate osteoclast formation through an intercellular interaction between osteoblasts and osteoclast precursors 2554316289620 periodontitis LPS promote PGE2 production 2564316289620 periodontitis LPS increase expression of COX-2 2574316289620 periodontitis expression of COX-2 promote PGE2 production 2584316289620 periodontitis LPS promote the production of PGE receptor EP4 subtype in osteoblasts 2594316289620 periodontitis LPS-induced PGE2 combine with osteoblast PGE receptor EP4 subtype in autocrine or paracrine modes 2604316289620 periodontitis LPS-induced PGE2 promote the formation of osteoclasts 2614416277578 periodontitis individuals with advanced rheumatoid arthritis(RA) more likely to experience more significant problems on periodontitis 2624516277573 periodontitis Activated T lymphocytes be implicated in experimental periodontal bone resorption 2634516277573 periodontitis antigen-specific T lymphocytes and gingival instillation of antigen and LPS be required for bone resorption 2644516277573 periodontitis Interference with co-stimulatory interactions between T cells and antigen-presenting cells abrogate bone resorption 2654516277573 periodontitis Interference with costimulatory interactions between T cells and antigen-presenting cells emphasize the significance of immune response 2664516277573 periodontitis RANKL be expressed on T lymphocytes in human periodontitis disease 2674516277573 periodontitis systemic administration of osteoprotegerin(OPG), the decoy receptor for RANKL result in interferes RANKL activity 2684516277573 periodontitis RANKL regulate T cell-mediated bone resorption 2694516277573 periodontitis treatment of T cell-transferred rats with kaliotoxin (a scorpion venom potassium channel inhibitor) decrease T-cell RANKL expression 2704516277573 periodontitis treatment of T cell-transferred rats with kaliotoxin (a scorpion venom potassium channel inhibitor) diminish induction of RANKL-dependent osteoclastogenesis 2714516277573 periodontitis treatment of T cell-transferred rats with kaliotoxin (a scorpion venom potassium channel inhibitor) abrogate bone resorption 2724516277573 periodontitis adoptive transfer of antigen-specific B cells increase bone resorption 2734516277573 periodontitis RANKL-expressing B cells increase bone resorption 2744516277573 periodontitis infection with the antigen-bearing Actinobacillus actinomycetemcomitans increase bone resorption 2754516277573 periodontitis B cells mediate bone resorption 2764516277573 periodontitis B cells express RANKL 2774516277573 periodontitis RANKL expression mediate bone resorption 2784516277573 periodontitis prominent T lymphocytes elevate RANKL mRNA expression 2794516277573 periodontitis prominent T lymphocytes decrease OPG mRNA expression 2804516277573 periodontitis inhibition of RANKL activity ameliorate bone resorption 2814516277573 periodontitis diminishing immune cell stimulation ameliorate bone resorption 2824616266722 periodontitis lipopolysaccharide(LPS) from the cell wall of Gram-negative bacteria cause alveolar bone destruction 2834616266722 periodontitis nicotine and LPS stimulate the formation of osteoclast-like cells 2844616266722 periodontitis nicotine and LPS increase M-CSF and PGE2 production 2854616266722 periodontitis M-CSF and PGE2 production stimulate the formation of osteoclast-like cells 2864716253089 periodontitis activated T lymphocytes secrete receptor activator of nuclear factor-kappa B ligand(RANKL) 2874716253089 periodontitis Activated T lymphocytes support the differentiation of monocytes into resorbing osteoclasts(OCs) 2884716253089 periodontitis T cells from peripheral blood mononuclear cells (PBMCs) of periodontitis patients (PP) overexpress RANKL 2894716253089 periodontitis T cells from peripheral blood mononuclear cells (PBMCs) of periodontitis patients (PP) overexpress TNF-alpha 2904716253089 periodontitis anti- RANKL and anti- TNF-alpha antibodies inhibit osteoclastogenesis 2924915996190 periodontitis Capsular polysaccharide from Actinobacillus actinomycetemcomitans Y4 (Y4 CP) induce bone resorption 2934915996190 periodontitis Capsular polysaccharide from Actinobacillus actinomycetemcomitans Y4 (Y4 CP) inhibit IL-6 from human gingival fibroblast (HGF) 2944915996190 periodontitis Capsular polysaccharide from Actinobacillus actinomycetemcomitans Y4 (Y4 CP) inhibit IL-8 from human gingival fibroblast (HGF) 2954915996190 periodontitis Capsular polysaccharide from Actinobacillus actinomycetemcomitans Y4(Y4 CP)-treated THP-1 cells, which are a human monocytic cell line induce IL-1beta mRNA 2964915996190 periodontitis Capsular polysaccharide from Actinobacillus actinomycetemcomitans Y4(Y4 CP)-treated THP-1 cells, which are a human monocytic cell line induce TNF-alpha mRNA 2974915996190 periodontitis PD98059 inhibits extracellular signal-regulated kinase 2984915996190 periodontitis SB203580 inhibits p38 kinase 2994915996190 periodontitis SB203580, a specific inhibitor of p38 kinase prevent IL-1beta expression induced by Capsular polysaccharide from Actinobacillus actinomycetemcomitans Y4(Y4 CP) 3004915996190 periodontitis JNK Inhibitor II, a specific inhibitor of c-Jun N-terminal kinase(JNK) prevent IL-1beta mRNA expression induced by Capsular polysaccharide from Actinobacillus actinomycetemcomitans Y4 (Y4 CP) 3014915996190 periodontitis Capsular polysaccharide from Actinobacillus actinomycetemcomitans Y4(Y4 CP)-mediated JNK pathways play an important role in the regulation of IL-1beta mRNA 3035115898943 periodontitis Porphyromonas gingivalis, Treponema denticola, and Treponema socranskii induce osteoclast formation 3045115898943 periodontitis Porphyromonas gingivalis, Treponema denticola, and Treponema socranskii increase expression of RANKL and PGE2 3055115898943 periodontitis Porphyromonas gingivalis, Treponema denticola, and Treponema socranskii decrease expression of OPG in osteoblasts 3065115898943 periodontitis The addition of osteoprotegerin(OPG), an inhibitor of RANKL suppress osteoclastogenesis 3075115898943 periodontitis Porphyromonas gingivalis, Treponema denticola, and Treponema socranskii stimulate osteoclastogenesis 3085115898943 periodontitis Indomethacin, which is an inhibitor of PGE2 synthesis reduce osteoclast formation 3095115898943 periodontitis Porphyromonas gingivalis, Treponema denticola, and Treponema socranskii induce osteoclast formation 3105115898943 periodontitis indomethacin inhibit RANKL expression in osteoblasts 3115115898943 periodontitis Porphyromonas gingivalis, Treponema denticola, and Treponema socranskii induce RANKL expression in osteoblasts 3125115898943 periodontitis indomethacin recover depression of OPG expression in osteoblasts 3135115898943 periodontitis Porphyromonas gingivalis, Treponema denticola, and Treponema socranskii induce RANKL-dependent pathway and osteoclastogenesis 3145115898943 periodontitis PGE2 enhances RANKL expression 3155115898943 periodontitis PGE2 enhances depression of osteoprotegerin, a RANKL inhibitor 3165215780952 periodontitis inflammatory cytokines such as interleukin-1(IL-1) and prostaglandin E2(PGE2) result in alveolar bone destruction 3175215780952 periodontitis IL-1alpha induce tartrate-resistant acid phosphatase(TRAP) positive cell formation 3185215780952 periodontitis IL-1alpha up-regulate receptor activator of NF-kappaB ligand(RANKL) 3195215780952 periodontitis IL-1alpha down-regulate osteoprotegerin(OPG) mRNA expression 3205215780952 periodontitis cell-permeable PKI, an inhibitor of the cAMP/PKA signaling pathway inibit IL-1alpha-induced TRAP positive cell formation 3215215780952 periodontitis NS398, a selective inhibitor of cyclooxygenase-2 block IL-1alpha-induced TRAP positive cell formation 3225215780952 periodontitis PD98059, a specific inhibitor of extracellular signal-regulated kinase(ERK) block IL-1alpha-induced TRAP positive cell formation 3235215780952 periodontitis NS398 and PD98059 inhibit up-regulation of RANKL expression 3245215780952 periodontitis NS398 and PD98059 inhibit down-regulation of OPG expression 3255215780952 periodontitis IL-1alpha activate ERK phosphorylation 8005215780952 PD98059 greatly inhibit both COX-2 mRNA expression and PGE2 production induced by IL-1alpha 3265215780952 periodontitis NEMO binding domain (NBD) peptide inhibits NF-kappaB signaling 3275215780952 periodontitis NEMO binding domain (NBD) peptide not affect COX2, RANKL, nor OPG mRNA expression induced by IL-1alpha 3285215780952 periodontitis IL-1alpha stimulate osteoclast formation 3295215780952 periodontitis IL-1alpha increase expression level of RANKL via ERK-dependent PGE2 production 3305315732858 periodontitis receptor activator of nuclear factor kappaB ligand(RANK-L) regulate osteoclastogenesis 3315315732858 periodontitis total amount of RANK-L be significantly increased in gingival crevicular fluid of periodontitis 3325415693607 periodontitis receptor activator NFkappaB(RANK), its ligand, RANKL (also known as TRANCE, osteoclast differentiation factor and osteoprotegerin (OPG) ligand) and the natural RANKL inhibitor, osteoprotegerin(OPG) regulate osteoclast formation 3335515618171 periodontitis receptor activator of NF-kappaB ligand(RANKL) and osteoprotegerin(OPG) regulate osteoclast formation and bone resorption 3345515618171 periodontitis RANKL induce osteoclast differentiation and activation 3355515618171 periodontitis osteoprotegerin(OPG) ,acting as a decoy receptor for RANKL block osteoclast differentiation and activation 3365515618171 periodontitis A. actinomycetemcomitans affects on the expression of RANKL and OPG in Human gingival fibroblasts (HGF) and periodontal ligament cells 3375515618171 periodontitis A. actinomycetemcomitans induce RANKL expression 3405815476591 osteolysis parthenolide(PAR), an NF-kappaB inhibitor block LPS-induced osteolysis 3415815476591 osteolysis parthenolide(PAR), an NF-kappaB inhibitor inhibit osteoclastogenesis and bone resorption 3425815476591 osteolysis parthenolide(PAR), an NF-kappaB inhibitor suppress NF-kappaB activity and promote apoptosis of osteoclasts 3435815476591 osteolysis chronic infection of gram-negative bacteria induce osteolysis 3445815476591 osteolysis parthenolide(PAR) block LPS-induced osteolysis 3455815476591 osteolysis parthenolide(PAR) inhibit LPS-induced NF-kappaB activation 3475815476591 osteolysis parthenolide(PAR) inhibit I-kappaB-alpha degradation 3485815476591 osteolysis parthenolide(PAR) inhibit NF-kappaB activation 3495815476591 osteolysis osteoclastogenic factors RANKL, interleukin-1beta, or TNF-alpha induce NF-kappaB activation 3505815476591 osteolysis parthenolide(PAR) reduce gene expression of RANK 3515815476591 osteolysis parthenolide(PAR) reduce gene expression of TRAF6 3525815476591 osteolysis NF-kappaB pathway mediate osteoclast differentiation and osteoclast survival 3535815476591 osteolysis parthenolide(PAR) block LPS-induced osteolysis 3545815476591 osteolysis parthenolide(PAR) suppress NF-kappaB activity 3566015375775 periodontitis The intercellular communication between osteoblasts and osteoclasts be crucial to bone homeostasis 3576115336598 periodontitis human periodontal ligament fibroblasts secrete bioactive osteoprotegerin(OPG) 3586115336598 periodontitis osteoprotegerin(OPG) inhibit osteoclastic differentiation 3596115336598 periodontitis human periodontal ligament fibroblasts (HPLF) regulate bone metabolism in the presence of lipopolysaccharide(LPS) 3606115336598 periodontitis Escherichia coli Lipopolysaccharide increase expression of IL-1 beta and TNF-alpha mRNA 3616115336598 periodontitis IL-1 beta or TNF-alpha induce osteoprotegerin(OPG) and RANKL expression 3626115336598 periodontitis The administration of neutralizing antibodies against human IL-1 beta or TNF-alpha Have a higher incidence of and more severe periodontitis 3636115336598 periodontitis LPS up-regulate IL-1 beta and TNF-alpha 3646115336598 periodontitis LPS stimulate both osteoprotegerin(OPG) and RANKL expression in human periodontal ligament fibroblasts (HPLF) 3656215257746 periodontitis MMPs and RANKL express similarly in aggressive periodontitis(AP) and chronic periodontitis(CP) 3666215257746 periodontitis TNF-alpha express similarly in aggressive periodontitis(AP) and chronic periodontitis(CP) 3676215257746 periodontitis respective tissue inhibitors of metalloproteinases(TIMPs) and OPG express higher in chronic periodontitis(CP) than aggressive periodontitis(AP) 3686215257746 periodontitis IFN-gamma express higher in chronic periodontitis(CP) than aggressive periodontitis(AP) 3696215257746 periodontitis IL-10 express lower in chronic periodontitis(CP) than aggressive periodontitis(AP) 3706315257734 periodontitis LPS Salmonella typhimurium induce periodontal inflammation 3716315257734 periodontitis LPS injection result in periodontal inflammation 3726415156202 periodontitis NF-kappa B be crucial in osteoclast differentiation 3736415156202 periodontitis blocking NF-kappa B prevent inflammatory bone resorption 3746415156202 periodontitis I kappa B-kinase complex be crucial in the signal transduction pathways to NF-kappa B 3756415156202 periodontitis a cell-permeable peptide inhibitor of the I kappa B-kinase complex inhibit RANKL-stimulated NF-kappa B activation and osteoclastogenesis 3766415156202 periodontitis a cell-permeable peptide inhibitor of the I kappa B-kinase complex reduce the severity of collagen-induced arthritis in mice by reducing levels of tumor necrosis factor-alpha and interleukin-1 beta, abrogating joint swelling and reducing bone destruction and cartilage 3776415156202 periodontitis selective inhibition of NF-kappa B activation induce an effective therapeutic approach for inhibiting chronic inflammatory diseases involving bone resorption 3796614971246 periodontitis anti-proteinases agents inhibits matrix metalloproteinases, which is postulated to be of therapeutic value as an adjunctive therapy to the management of chronic periodontitis 3806614971246 periodontitis anti-inflammatory drugs inhibits proinflammatory cytokines and prostaglandins, which is postulated to be of therapeutic value as an adjunctive therapy to the management of chronic periodontitis 3816614971246 periodontitis bone-sparing agents inhibits osteoclasts, which is postulated to be of therapeutic value as an adjunctive therapy to the management of chronic periodontitis 3826714753747 periodontitis Systemic administration of kaliotoxin abrogate bone resorption in conjunction with decreased RANKL mRNA expression by T-cells in gingival tissue 3836714753747 periodontitis kaliotoxin decrease RANKL mRNA expression 3846714753747 periodontitis Kv1.3 is a critical potassium channel counterbalances calcium influx at T-cell receptor activation 3856714753747 periodontitis kaliotoxin decrease T-cell activation parameters of 29-kDa outer membrane protein-specific Th1 clone cells in vitro and in vivo 3866714753747 periodontitis kaliotoxin-treatment T-cells recovered from the gingival tissue of rats display lower ratios of RANKL and osteoprotegerin(OPG) mRNA expression than control 3876714753747 periodontitis kaliotoxin treatments in vitro decreases RANKL and osteoprotegerin protein expression 3886714753747 periodontitis kaliotoxin treatments in vitro induces of RANKL-dependent osteoclastogenesis by the activated T-cells 3896814742657 periodontitis RANKL play an important role in osteoclast formation 3906814742657 periodontitis gingival crevicular fluid(GCF) from patients with periodontitis increase of RANKL and decrease of osteoprotegerin(OPG) 3916814742657 periodontitis concentration of RANKL in the gingival crevicular fluid(GCF) be significantly higher for periodontal disease patients than concentration of osteoprotegerin(OPG) 3926814742657 periodontitis RANKL and osteoprotegerin(OPG) contribute to osteoclastic bone destruction in periodontal disease. 3957114659542 periodontitis Porphyromonas gingivalis be etiological agent of adult periodontitis 3977114659542 periodontitis a 41-kDa fimbrillin of P. gingivalis ATCC 33277 induce inflammatory cytokine production in murine peritoneal macrophages 3987114659542 periodontitis P. gingivalis 67-kDa minor fimbriae induce IL-1 beta production 3997114659542 periodontitis P. gingivalis 67-kDa minor fimbriae induce TNF-alpha production 4007114659542 periodontitis P. gingivalis 67-kDa minor fimbriae induce IL-6 production 4017114659542 periodontitis Pretreatment with anti-Toll-like receptor 2(TLR2) antibody significantly inhibit IL-1 beta induction 4027114659542 periodontitis Pretreatment with anti-Toll-like receptor 2(TLR2) antibody significantly inhibit TNF-alpha induction 4037114659542 periodontitis Pretreatment with anti-Toll-like receptor 2(TLR2) antibody significantly inhibit IL-6 induction 4047114659542 periodontitis P. gingivalis 67-kDa minor fimbriae may provoke host inflammatory response and be involved in periodontal tissue breakdown. 4057214646592 periodontitis activated B cells enhance osteoclastogenesis 4067214646592 periodontitis activated CD8positive T cell suppress osteoclastogenesis 4077214646592 periodontitis B cells activated in the presence of Th1 cytokines inhibit osteoclastogenesis 4087214646592 periodontitis anti-IgD monoclonal antibody, IL-4, and anti-CD40 monoclonal antibody activate B cell, in the absence (BTh2) or presence of Th1 cytokines, either IL-2 (BIL-2) or IFN-gamma (BIFN-gamma) 4137214646592 periodontitis IFN-gamma negatively regulate osteoclastic differentiation 4147214646592 periodontitis IFN-gamma mediate the inhibition of osteoclastogenesis by IL-2 from B cell 4157214646592 periodontitis Th1 cytokines act directly on osteoclasts or indirectly through B cells 4167314525917 periodontitis inflammation after bacterial insult induce bone resorption, which is followed by new reparative bone formation 4177314525917 periodontitis diabetes patints have a higher incidence of and more severe periodontitis 4187314525917 periodontitis diabetes decrease osteoclastogenesis 4197314525917 periodontitis diabetes reduce bone formation 4207314525917 periodontitis diabetes enhance apoptosis of osteoblastic cells in bacteria stimulated bone loss 4217412828654 periodontitis osteoprotegerin(OPG) inhibit receptor activator of nuclear factor kappaB ligand(RANKL) 4227412828654 periodontitis periodontitis tissue express significantly higher levels of RANKL protein (P < 0.05) 4237412828654 periodontitis periodontitis tissue express significantly lower OPG protein (P < 0.05) 4247412828654 periodontitis RANKL protein be associated with lymphocytes and macrophages 4257412828654 periodontitis osteoprotegerin(OPG) protein be associated with endothelial cells 4267412828654 periodontitis leukocytes express RANK mRNA 4277412828654 periodontitis leukocytes express TRAP 4287512816291 periodontitis Incadronate (YM175, disodium cycloheptylaminomethylenediphosphonate monohydrate), a bisphosphonate inhibit osteoclast activity 4297512816291 periodontitis Incadronate (YM175, disodium cycloheptylaminomethylenediphosphonate monohydrate), a bisphosphonate prevent bone resorption 4307512816291 periodontitis P. gingivalis infection induce destruction of periodontal ligament 4317512816291 periodontitis P. gingivalis infection reduce bone density 4327512816291 periodontitis P. gingivalis infection cause inflammatory cell migration 4337512816291 periodontitis incadronate increase bone mineral density 4347512816291 periodontitis incadronate prevent destruction of periodontal ligament 4357512816291 periodontitis incadronate decrease polymorphonuclear leukocyte(PMN) infiltration in gingival tissue 4367512816291 periodontitis incadronate inhibit bone resorption 4377612816291 periodontitis TRANCE signaling be crucial for proper bone homeostasis 4387712761894 periodontitis nitric oxide be a potentially important mediator of bone resorption 4397712761894 periodontitis Nitric oxide synthase-1 -/- knockout mice demonstrate a significantly reduced osteoclast response 4407712761894 periodontitis Nitric oxide synthase-1 play a critical role in inflammatory bone resorption and osteoclast function in vitro 4417812710761 periodontitis IL-1 and TNF act as proinflammatory cytokines 4427812710761 periodontitis IL-1 and TNF induce adhesion molecules and other mediators that facilitate and amplify the inflammatory response, the stimulation of matrix metalloproteinase, and bone resorption 4437812710761 periodontitis TNF mediate loss of fibroblasts 4447812710761 periodontitis excessive production of IL-1 and TNF cause an overreaction of the host response to periodontal pathogens 4468012608914 periodontitis a capsular polysaccharide(CP) from Actinobacillus actinomycetemcomitans Y4 induce bone resorption 4478012608914 periodontitis a capsular polysaccharide(CP) from Actinobacillus actinomycetemcomitans Y4 inhibit the release of IL-6 and IL-8 from Human gingival fibroblasts (HGF) 4488012608914 periodontitis A. actinomycetemcomitans Y4 modulate the inflammatory response in periodontitis 4498112496170 periodontitis Treponema denticola be involved in periodontitis 4508112496170 periodontitis lipooligosaccharide from Treponema denticola affect osteoclast formation, expression of osteoclast differentiation factor and osteoprotegerin mRNAs 4518112496170 periodontitis lipooligosaccharide from Treponema denticola affect expression of matrix metalloproteinases 4528112496170 periodontitis matrix metalloproteinases(MMPs) be involved in bone resorption 4538112496170 periodontitis LPS increase expression of osteoclast differentiation factor (ODF) mRNA 4548112496170 periodontitis LPS decrease expression of osteoprotegerin(OPG) 4558112496170 periodontitis Polymyxin B change the effect of LPS on osteoclast differentiation factor (ODF) and osteoprotegerin(OPG) mRNA expression to the control level. 4568112496170 periodontitis LPS stimulate PGE2 production 4578112496170 periodontitis indomethacin inhibit prostaglandin synthesis 4588112496170 periodontitis T. denticola LPS increase the levels of mRNAs encoding MMP-3, MMP-8, MMP-9, MMP-10, MMP-13, and MMP-14 4598112496170 periodontitis T. denticola LPS significantly induce MMP-9 mRNA 4608112496170 periodontitis T. denticola LPS stimulate osteoclastogenesis 4618112496170 periodontitis T. denticola LPS stimulate MMP expression 4628112496170 periodontitis PGE2-dependent mechanism up-regulate osteoclast differentiation factor (ODF) in the osteoclastogenesis induced by T. denticola lipooligosaccharide(LOS) 4638112496170 periodontitis PGE2-dependent mechanism down-regulation of OPG in the osteoclastogenesis induced by T. denticola lipooligosaccharide(LOS) 4648212469211 periodontitis RANKL, a novel TNF receptor-related protein be an important factor for osteoclast differentiation and osteoclast activation 4658212469211 periodontitis RANKL mRNA increase in periodontitis compared to OPG mRNA 4668212469211 periodontitis up regulation of RANKL mRNA in both inflammatory cells and epithelium may be associated with the activation of osteoclastic bone destruction in periodontitis 4698512390325 periodontitis Activated T lymphocytes secrete receptor activator of NF-kappaB ligand(RANKL) 4708512390325 periodontitis Activated T lymphocytes support the differentiation of monocytes into mature osteoclasts 4718512390325 periodontitis LPS-stimulated gingival fibroblasts reduce the number of TRAP positive monocytes 4728512390325 periodontitis culturing monocytes with RANKL and M-CSF generate TRAP positive monocytes 4738512390325 periodontitis LPS-stimulated Human gingival fibroblasts (HGF) inhibit monocyte differentiation into osteoclasts through the production of OPG 4748612354082 periodontitis Th1 cells discharge Interleukin-2, a proinflammatory cytokine 4758612354082 periodontitis IL-2 be involved in activatation of B-cell 4768612354082 periodontitis IL-2 stimulate macrophage 4778612354082 periodontitis IL-2 be implicated in the stimulation of osteoclast activity in bone resorption 4788712146541 periodontitis bisphosphonates inhibit bone resorption 4798712146541 periodontitis bisphosphonates increase osteoblastic differentiation 4808712146541 periodontitis bisphosphonates inhibit osteoclast recruitment and activity 4818712146541 periodontitis bisphosphonates stimulate osteogenesis 4828712146541 periodontitis bisphosphonates promote bone formation 4838812146531 periodontitis Chemically modified tetracyclines (CMTs) be devoid of anti-microbial acti-vity 4848812146531 periodontitis Chemically modified tetracyclines (CMTs) inhibit pathologically elevated collagenase activity 4858812146531 periodontitis doxycycline and 5 different Chemically modified tetracyclines (CMTs) prevent matrix metalloproteinase(MMP)-dependent periodontal tissue breakdown 4868812146531 periodontitis Escherichia coli endotoxin injection induce elevated gelatinase(GLSE) activity in osteoclast-mediated bone resorption 4878812146531 periodontitis doxycycline and 5 different Chemically modified tetracyclines (CMTs) inhibit periodontal breakdown 4888812146531 periodontitis treatment with Chemically modified tetracyclines (CMTs) decrease the number of immuno-positive stained cells for cytokines and MMPs 4898812146531 periodontitis both conventional (anti-microbial) and non-anti-microbial tetracyclines inhibit periodontal bone resorption induced by endotoxin injection 4908812146531 periodontitis MMP-mediated bone loss prevent inhibition of MMPs 4918912097235 periodontitis interleukin-1, prostaglandin E2 and metalloproteinases mediate periodontal disease 4929012087965 periodontitis agents for host modulators include Periostat, non-steroidal anti-inflammatory agents, alendronate(Fosamax), hormone replacement therapy and anti-arthritic medications inhibit matrix metalloproteinases 4939012087965 periodontitis agents for host modulators include Periostat, non-steroidal anti-inflammatory agents, alendronate(Fosamax), hormone replacement therapy and anti-arthritic medications inhibit prostaglandin production 4949012087965 periodontitis agents for host modulators include Periostat, non-steroidal anti-inflammatory agents, alendronate(Fosamax), hormone replacement therapy and anti-arthritic medications stimulete osteoblasts 4959012087965 periodontitis agents for host modulators include Periostat, non-steroidal anti-inflammatory agents, alendronate(Fosamax), hormone replacement therapy and anti-arthritic medications inhibit osteoclasts 4969112030970 periodontitis proinflammatory cytokines [interleukin-1beta, IL-6, and tumor necrosis factor-alpha] be involved in bone resorption 4979112030970 periodontitis P. gingivalis and A. actinomycetemcomitans elicite mRNA expression proinflammatory cytokines interleukin-1beta, IL-6, and tumor necrosis factor-alpha 4989112030970 periodontitis Streptococcus gordonii induce only low levels of mRNA for IL-1beta and TNF alpha but no IL-6 mRNA induction 4999212027248 periodontitis clodronate prevent osteoclastic bone resorption in periodontitis 5009312011948 periodontitis Matrix metalloproteinases(MMP) initiate collagen degradation 5019312011948 periodontitis doxycycline(DX) inhibit MMP 5029312011948 periodontitis doxycycline(DX) inhibit bone resorption 5039312011948 periodontitis doxycycline(DX) inhbit inflammatory bone resorption 5049412011008 periodontitis Porphyromonas gingivalis, a periodontal pathogen, and Escherichia coli LPS induce osteoclastic cell formation 5059412011008 periodontitis tartrate-resistant acid phosphatase-positive cells be positive for RANK 5069412011008 periodontitis RANK be a receptor of RANKL 5079412011008 periodontitis P. gingivalis injection stimulate RANKL expression in both mononuclear leukocytes and osteoblastic cells 5089512009179 periodontitis human macrophage secrete 17beta-estradiol and proinflammatory lipopolysaccharide on histologic bone resorption 5099512009179 periodontitis 17beta-estradiol inhibit inflammatory bone resorption 5119711924589 periodontitis disodium chlodronate(CD), a bisphosphonate have both bone sparing and anti-inflammatory activity 5129811677904 periodontitis tetracyclines act as a broad-spectrum anti-microbial agent 5139811677904 periodontitis tetracyclines and their non-anti-microbial, chemically modified analogs inhibit the activity of the matrix metalloproteinases that cause collagen destruction 5149811677904 periodontitis tetracyclines and their non-anti-microbial, chemically modified analogs inhibit osteoclast function 5159811677904 periodontitis tetracyclines and their non-anti-microbial, chemically modified analogs stimulate osteoblastic bone formation 5169811677904 periodontitis tetracyclines and their non-anti-microbial, chemically modified analogs regulate angiogenesis 51810011449372 periodontitis M-CSF induce osteoclast differentiation in CD4positive B cells, but not in CD8 positive T cells 51910011449372 periodontitis M-CSF and soluble RANKL induce the formation of small but highly active osteoclasts and increased osteoclasts resorption in B cells 52010011449372 periodontitis M-CSF and soluble RANKL induce profoundly suppress of osteoclastogenesis in CD8positive T cells 52110011449372 periodontitis Activated B cells express osteoclastogenic factors including RANKL, TNF-alpha, IL-6, MIP-1alpha, and MCP-3 52210011449372 periodontitis OPG along with RANKL be substantially expressed in CD8 positive T cells 52310011449372 periodontitis Activated B cells promote osteoclastogenesis 52410011449372 periodontitis CD8 positive T cells inhibit osteoclast formation 52510111379890 periodontitis soluble factor(s) produced from Periodontal ligament(PDL) cells inhibit the formation of tartrate-resistant acid phosphatase(TRAP)-positive multinucleated cells 52610111379890 periodontitis Periodontal ligament(PDL) cells support osteoclastogenesis through cell-to-cell contact with peripheral blood mononuclear cells (PBMCs) 52810111379890 periodontitis resorptive action by RANKL in Periodontal ligament(PDL) cells regulate osteoclastogenesis 52910111379890 periodontitis inhibitary action by OPG in Periodontal ligament(PDL) cells regulate osteoclastogenesis 53010211345523 periodontitis peripheral infection involving organism of gram-negative bacteria cause Periodontal disease 53110211345523 periodontitis periodontal disease cause dense inflammatory infiltrate involving T-lymphocytes 53210211345523 periodontitis CD4 positive T-cellsand CD8 positive T-cells presenting in periodontal lesions act as activated memory T-lymphocytes 53310211345523 periodontitis Th1-type T-cells up-regulate the production of proinflammatory cytokines IL-1 and TNF-alpha 53410211345523 periodontitis IL-1 and TNF-alpha induce bone resorption 53510211345523 periodontitis IL-1 and TNF-alpha promote osteoclast differentiation 53610211345523 periodontitis IL-1 and TNF-alpha activate osteoclasts 53710211345523 periodontitis osteoprotegerin ligand(OPGL) production promote osteoclast differentiation 53810211345523 periodontitis production and expression of osteoprotegerin ligand(OPGL) activate T-cells 53910211345523 periodontitis activated T-cells promote osteoclast differentiation 54010211345523 periodontitis osteoprotegerin ligand(OPGL) be predominantly expressed on Th1-type cells 54110211345523 periodontitis chemokines/chemokine receptors regulate T-cell recruitment into inflamed gingival tissues 54210211345523 periodontitis adhesion molecules including alpha4 integrin, alpha6 integrin, LFA-1, and ICAM-1 regulate T-cell recruitment into inflamed gingival tissues 54310211345523 periodontitis Th1-type T-cells express CCR5 and CXCR3 54410211345523 periodontitis Th2-type T-cells express CCR5 54510211345523 periodontitis inflamed periodontal tissues elevate the chemokine ligands RANTES, MIP1-alpha (both CCR5), and IP-10 (CXCR3 ligand) 54710411207318 periodontitis osteoclast differentiation factor (ODF) , a recently identified cytokine of the TNF family be expressed as a membrane-associated protein in osteoblasts and stromal cells. 54810411207318 periodontitis osteoclast differentiation factor (ODF) stimulate the differentiation of osteoclast precursors into osteoclasts in the presence of M-CSF 54910411207318 periodontitis LPS increase the osteoclast differentiation factor (ODF) mRNA level 55010411207318 periodontitis A specific inhibitor of extracellular signal-regulated kinase or protein kinase C inhibit up-regulation ofthe osteoclast differentiation factor (ODF) mRNA level 55110411207318 periodontitis LPS induce osteoclast differentiation factor (ODF) mRNA 55210411207318 periodontitis TLR2 and TLR4 act as putative LPS receptors 55310411207318 periodontitis TLR2 and TLR4 be constitutively expressed in mouse osteoblasts 55410411207318 periodontitis LPS treatment via TLR increase osteoclast differentiation factor (ODF) gene expression in osteoblasts 55610611083800 periodontitis prostaglandin E receptor 4 and LPS induce osteoclast formation in vitro. 55710611083800 periodontitis the reduced osteoclast differentiation factor (ODF) expression and apparently increased osteoclastgenesis inhibitory factor (OCIF) expression reduce LPS-induced bone resorption 55810611083800 periodontitis PGE receptor EP4 subtype be involved in LPS-induced bone resorption 55910710995794 periodontitis Actinobacillus actinomycetemcomitans activate human CD4 positive T cells in the periodontium 56010710995794 periodontitis Actinobacillus actinomycetemcomitans trigger local alveolar bone destruction 56110710995794 periodontitis Stimulation of CD4 positive T cells by A. actinomycetemcomitans induce production of osteoprotegerin ligand(OPG-L) 56210710995794 periodontitis osteoprotegerin ligand(OPGL) be a key modulator of osteoclastogenesis and osteoclast activation 56310710995794 periodontitis inhibition of osteoprotegerin ligand(OPGL) function with the decoy receptor OPG diminish alveolar bone destruction 56410710995794 periodontitis inhibition of osteoprotegerin ligand(OPGL) function with the decoy receptor OPG reduce the number of periodontal osteoclasts 56510710995794 periodontitis microorganism-triggered induction of osteoprotegerin ligand(OPGL) expression on CD4 positive T cells and the consequent activation of osteoclasts mediate alveolar bone destruction observed in periodontal infections 56610710995794 periodontitis Inhibition of osteoprotegerin ligand(OPGL) prevent alveolar bone loss 56710810914805 periodontitis prostaglandins be implicated in periodontal bone destruction 56810810914805 periodontitis a non-selective cyclooxygenase(COX) inhibitor (indomethacin-IND) or a type 2 COX inhibitor(meloxicam-MLX) reduce alveolar bone loss and histopathologic changes 56910810914805 periodontitis COX inhibition prevent alveolar bone loss 57010910768725 periodontitis Chlorpromazine(CPZ), a phenothiazine derivative possesse anti-inflammatory properties 57110910768725 periodontitis Chlorpromazine(CPZ) inhibit tumor necrosis factor-alpha(TNF-alpha) synthesis 57210910768725 periodontitis chlorpromazine(CPZ) inhibit bone resorption 57310910768725 periodontitis TNF-alpha promote inflammation and bone resorption 57410910768725 periodontitis CPZ reduce bone loss 57510910768725 periodontitis CPZ block TNF-alpha 57711110674961 periodontitis IL-1 activate osteoclastic bone resorption 57811210471155 periodontitis osteoclasts mediate bone resorption 57911210471155 periodontitis lipopolysaccharide(LPS) induce osteoclast differentiation from haemopoietic cells 58011210471155 periodontitis inflammatory mediators such as interleukin-1(IL-1) and prostaglandin E2(PGE2) induce osteoclast differentiation from haemopoietic cells 58111210471155 periodontitis 2-aminoethanesulphonic acid inhibit the stimulation of bone resorption mediated by LPS of the periodontopathic microorganism Actinobacillus actinomycetemcomitans Y4 58211210471155 periodontitis 2-aminoethanesulphonic acid affect on the development and survival of osteoclast-like multinucleated cells 58311210471155 periodontitis 2-aminoethanesulphonic acid suppress the formation of these osteoclast-like cells in the presence of LPS of A. actinomycetemcomitans Y4, IL-1alpha or PGE2 58411210471155 periodontitis IL-1alpha elongate the survival of the osteoclast-like cells 58511210471155 periodontitis 2-aminoethanesulphonic acid block the supportive effect of IL-1alpha on osteoclast survival 58611210471155 periodontitis 2-aminoethanesulphonic acid inhibit alveolar bone resorption 58711210471155 periodontitis 2-aminoethanesulphonic acid prevent inflammatory bone resorption 58811310371246 periodontitis Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) be implicated in localized juvenile periodontitis(LJP) 58911310371246 periodontitis Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) produce of a multiplicity of tissue-damaging products 59011310371246 periodontitis capsular-like polysaccharide antigen(CPA) promote osteoclast-like cell formation 59111310371246 periodontitis capsular-like polysaccharide antigen(CPA) produce IL-1alpha 59211310371246 periodontitis IL-1alpha production promote osteoclast-like cell formation 59311310371246 periodontitis capsular-like polysaccharide antigen(CPA) from A. actinomycetemcomitans be associated to apoptotic cell death 59411310371246 periodontitis capsular-like polysaccharide antigen(CPA) from A. actinomycetemcomitans induce Fas system 59511310371246 periodontitis Fas pathway mediate apoptosis 5991179972123 periodontitis collagenase (matrix metalloproteinase) be associated with osseous destructive diseases 6001179972123 periodontitis anti-matrix metalloproteinase effects of tetracyclines(TCs), non-anti-microbial, chemically modified tetracyclines inhibit osteoclast function 6031179972123 periodontitis tetracyclines(TCs) inhibit bone resorption by diminishing the secretion of lysosomal cysteine proteinases(cathepsins) 6051179972123 periodontitis tetracyclines(TCs) inhibit bone resorption by inhibiting osteoclast gelatinase activity 6061179972123 periodontitis tetracyclines(TCs) inhibit bone resorption by selectively inhibiting osteoclast ontogeny or development 6071179972123 periodontitis tetracyclines(TCs) inhibit bone resorption by inducing apoptosis or programmed cell death of osteoclasts 6081179972123 periodontitis tetracyclines(TCs), non-anti-microbial, chemically modified tetracyclines affect osteoclast function 6091179972123 periodontitis tetracyclines(TCs) inhibit bone resorption 6101179972123 periodontitis tetracyclines(TCs), non-anti-microbial, chemically modified tetracyclines act similarly to bisphosphonates 6111189926773 periodontitis injection of soluble forms of IL-1 receptor and TNF receptor into interdental papillae inhibit IL-1 and TNF activity 6141219712762 periodontitis Porphyromonas gingivalis, Campylobacter rectus, and Fusobacterium nucleatum cause bone resorption 6151229672100 periodontitis IL-1 stimulate osteoclastic activity 6171249579623 periodontitis macrophages and plasma cells be associated with osteoclastic activity 6181259551997 periodontitis IL-1 and TNF antagonists inhibit inflammatory response and bone loss 6191269294124 periodontitis LPS be central to the pathogenesis of osteolytic lesion 6201269294124 periodontitis LPS induce bone marrow macrophages(BMMs) to express c-src, a protooncogene product 6211269294124 periodontitis LPS induce TNF 6221269294124 periodontitis TNF induced by LPS augment c-src 6231269294124 periodontitis endotoxin induces expression of TNF in bone marrow macrophages 6241269294124 periodontitis TNF induced by endotoxin induce expression c-src in bone marrow macrophages 6251269294124 periodontitis thalidomide antagonize TNF action 6261269294124 periodontitis thalidomide attenuate induction of c-src by LPS 6271269294124 periodontitis An anti-TNF antibody block LPS enhancement of c-src mRNA 6281269294124 periodontitis p55 cytokine receptor mediate transmit induction of c-src by TNF 6291269294124 periodontitis TNF mediate LPS-induced osteoclastogenesis 6351328957930 periodontitis proinflammatory cytokines (interleukin 1 and interleukin 6, tumor necrosis factors) stimulate osteoclastic resorption 6361328957930 periodontitis immunoregulatory cytokines (interleukin 2 and interleukin 4, interferon gamma) decrease proinflammatory cytokines 6391358537916 periodontitis recombinant human interleukin-1 beta (rhIL-1 beta) accelerate alveolarbone destruction 6411377562325 periodontitis bisphosphonate(risedronate) prevent bone resorption 6431397776166 periodontitis Alendronate, an amino bisphosphonate inhibit bone loss 6441397776166 periodontitis Alendronate, an amino bisphosphonate alter osteoclast activity 6491438158502 periodontitis prostaglandin E1(PGE1) supress inflammation 6501438158502 periodontitis 15-M-prostaglandin E1, a stable prostaglandin E1(PGE1) analog improve gingival inflammation 6511438158502 periodontitis 15-M-prostaglandin E1, a stable prostaglandin E1(PGE1) analog reduce edema and polymorphonuclear leukocyte(PMNL) recruitment 6521448113951 periodontitis alendronate, a bisphosphate reduce bone loss 6531448113951 periodontitis alendronate, a bisphosphate inhibit osteoclast 6541458032451 periodontitis tetracyclines and their non-anti-microbial chemically modified analogs (chemically modified tetracycline molecules(CMTs)) inhibit extracellular activity of mammalian neutrophil and osteoblast collagenases 6551458032451 periodontitis matrix metalloproteinase destruct collagen 6561458032451 periodontitis tetracyclines inhibit osteoclast function 6571458032451 periodontitis tetracyclines and chemically modified tetracycline molecules (CMTs) reduce collagenase activity 6581458032451 periodontitis doxycycline reduce collagenase activity 6591458032451 periodontitis tetracyclines and chemically modified tetracycline molecules (CMTs) inhibit the activity of matrix metalloproteinases 6601458032451 periodontitis tetracyclines and chemically modified tetracycline molecules (CMTs) degradate osseous connective tissues 6611468410621 periodontitis tetracyclines and chemically modified tetracycline molecules (CMTs) inhibit the activity of the matrix metalloproteinase(MMP), collagenase. 6621468410621 periodontitis tetracyclines diminish bone resorption 6631468410621 periodontitis tetracyclines inhibit the activity of extracellular collagenase and other MMPs such as gelatinase 6641468410621 periodontitis tetracyclines prevent the activation of proenzyme of bone resorption by scavenging reactive oxygen organism generated by other cell types (e.g. PMNs, osteoclasts) 6651468410621 periodontitis tetracyclines inhibit the secretion of other collagenolytic enzymes (i.e. lysosomal cathepsins) 6661468410621 periodontitis tetracyclines affect other aspects of osteoclast structure and function 6671468410621 periodontitis tetracyclines and chemically modified tetracycline molecules (CMTs) reduce gingival collagenase activity and severity of periodontal breakdown 6701498430791 periodontitis platelet-activating factor(PAF), a potent inflammatory mediator act directly on isolated rat osteoclasts to elevate cytosolic free Ca(II) concentration ([Ca2+]i). 6711498430791 periodontitis platelet-activating factor(PAF) activate osteoclastic resorption 6721498430791 periodontitis platelet-activating factor(PAF) mediate resorption of bone 6751521328593 periodontitis Bisphosphonates induce increase of bone mass in estrogen-deficient patients 6761521328593 periodontitis Bisphosphonates inhibit osteoclast activity 6781542045580 periodontitis enzyme aspartate aminotransferase be used as a marker of periodontal disease progression 6801562145416 periodontitis Eikenella corrodens 1073-R(EcR) cause osteoclastic bone resorption 6821582128444 periodontitis Phenidone and ketoconazole inhibit leukotriene synthesis 6831582128444 periodontitis leukotrienes, particularly leukotriene B4 be involved in hamster periodontitis 6841582128444 periodontitis leukotrienes, particularly leukotriene B4 be responsible for polymorphonuclear leukocyte(PMNL) infiltration of the periodontal pocket 6851582128444 periodontitis decrease in polymorphonuclear leukocyte(PMNL) chemotaxis reduce inflammation 6881612489532 periodontitis IL-1 be analogous to TNF in osteoclast activation and promotion of bone resorption 6891622528622 periodontitis IL-1 activate osteoclast 6901622528622 periodontitis LPS, which is a potent polyclonal B-cell activators (PBA) factor in many systems elicit IL-1 production by B cells as well as by the monocyte/macrophage lineage 6911622528622 periodontitis malignant B-cell lines produce IL-1 6921622528622 periodontitis IL-1 in B cell be important in bone resorption 6931622528622 periodontitis Polyclonal B-cell activation lead to production of autoantibody such as anti-type 1 collagen and anti-type 3 collagen 6941622528622 periodontitis antibody-dependent cell-mediated cytotoxicity (ADCC) reactions induce the destruction of self tissues, immune complex formation, and complement activation 6951622528622 periodontitis periodontitis-associated bacteria contain potent polyclonal B-cell activators (PBA) factors 6961622528622 periodontitis alterations in the regulation of B-cell responses to polyclonal B-cell activators (PBA) factor are associated with severe periodontal disease 6971632768231 periodontitis indomethacin inhibit prostaglandin(PG)-synthesis 6981632768231 periodontitis indomethacin positively affect periodontitis of hamster