- Article -
| In Silico Biology 1, 0013 (1998); ©1998, Bioinformation Systems e.V. |
The Death Factors: a Combinatorial Analysis
Anne Bergeron, Paul Geanta1 and Dominique Bergeron2
1 LACIM, Université du Québec à Montréal, C.P. 8888 Succ. Centre-Ville, Montréal, Québec, Canada, H3C 3P8
E-mail: anne@lacim.uqam.ca
2 Département de microbiologie et immunologie, Université de Montréal, C.P. 6128 Centre-Ville, Montréal, Canada, H3C 3J7
E-mail: bergerdo@ere.umontreal.ca
Edited by T. Werner; received August 6, 1998; revised October 27, 1998; accepted November 17, 1998
Abstract
This paper presents theoretical and computational tools to understand how a small group of proteins, the death factors, are involved in widely different behavior of the cell. Experiments were done using a virtual laboratory that can simulate cellular response to different external stimuli.
WARNING: It is not certain which of the theoretical protein clusters
described here really occur in nature. In addition, the rules of cluster
assembly are combinatorial, and thus an oversimplification to describe
the real situation.
Key words: Key words: regulatory proteins, death factors, virtual experiments, signalization pathway