- Article -
| In Silico Biology 2, 0009 (2002); ©2002, Bioinformation Systems e.V. |
GeneNet database: Description and modeling of gene networks
Nikolay A. Kolchanov, Eugenia A. Nedosekina, Elena A. Ananko, Vitaly A. Likhoshvai, Nikolay L. Podkolodny, Alexander V. Ratushny, Irina L. Stepanenko, Olga A. Podkolodnaya, Elena V. Ignatieva and Yury G. Matushkin
Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
Edited by E. Wingender; received November 15, 2001; revised and accepted December 11, 2001; published February 27, 2002
Abstract
Almost all cellular processes in an organism are controlled by gene networks. Here we report on the analysis of gene networks functioning using two associated methods - data accumulation in GeneNet system and generalized chemical kinetic method for mathematical simulation of gene network functional dynamics. The technology of the usage of these methods is shown on the example of the gene network of macrophage activation.
Key words: gene network, modeling, mathematical simulation, database designing, macrophage