Integrating data from biological experiments into metabolic networks with the DBE information system
Ljudmilla Borisjuk, Mohammad-Reza Hajirezaei, Christian Klukas*, Hardy Rolletschek and Falk Schreiber
Institute of Plant Genetics and Crop Plant Research, Corrensstr. 3, D-06466 Gatersleben, Germany
Modern 'omics'-technologies result in huge amounts of data about life processes. For analysis and data mining purposes this data has to be considered in the context of the underlying biological networks. This work presents an approach for integrating data from biological experiments into metabolic networks by mapping the data onto network elements and visualising the data enriched networks automatically.
This methodology is implemented in DBE, an information system that supports the analysis and visualisation of experimental data in the context of metabolic networks. It consists of five parts: (1) the DBE-Database for consistent data storage, (2) the Excel-Importer application for the data import, (3) the DBE-Website as the interface for the system, (4) the DBE-Pictures application for the up- and download of binary (e. g. image) files, and (5) DBE-Gravisto, a network analysis and graph visualisation system.
The usability of this approach is demonstrated in two examples.
Keywords: metabolic networks, visualisation, metabolic profiling, information system, data integration