Alternatively Spliced Human Genes by Exon Skipping - a database (ASHESdb)
Meena Kishore Sakharkar1*, Bagavathi S. Perumal1, Yun Ping Lim2, Lee Pern Chern1, Yiting Yu1 and Pandjassarame Kangueane1
1 Nanyang Centre for Supercomputing and Visualization, Nanyang Technological University, Singapore 639798
Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. Exon skipping is the most commonly known alternative splicing mechanism. A comprehensive database of alternative splicing by exon skipping is made available for the human genome data. 1,229 human genes are identified to exhibit alternative splicing by exon skipping.
Keywords: alternative splicing, eukaryotic gene structure, exon skipping, multiple splice variants, protein isoforms, protein diversity, skipping patterns, genome wide splicing, full length cDNA sequences, tissue specificity, computational analysis, database