- Communication -

Volume 6

Full article

Social behavior of the yeast protein-protein interaction network

Aswin Sai Narain Seshasayee

EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SD, UK


Email: aswin@ebi.ac.uk


Edited by E. Wingender; received December 28, 2005; revised February 10, 2006; accepted February 11, 2006; published February 22, 2006

Abstract

Protein-protein interaction networks are useful in contextual annotation of protein function and in general to achieve a system-level understanding of cellular behavior. This work reports on the social behavior of the yeast protein-protein interaction network and concludes that it is non-random. This work, while providing an analysis of organization of genes into functional societies, can potentially be useful in assessing the accuracy of contextual gene annotation based on such interaction networks.

Keywords: protein-protein interaction, small world, clustering coefficient, pathway, contextual annotation