- Communication -

Volume 6

Full article

Huge proteins in the human proteome and their participation in hereditary diseases

Meena Kishore Sakharkar¹*, Pandjassarame Kangueane¹, Kishore Ramaji Sakharkar² and Zhaowei Zhong¹

¹ Nanyang Centre for Supercomputing and Visualization, MAE, Nanyang Technological University, Singapore 639798
² National University Medical Institute, National University of Singapore, Singapore


* Corresponding author
  Email: mmeena@ntu.edu.sg


Edited by E. Wingender; received March 25, 2006; revised May 10, 2006; accepted May 11, 2006; published June 03, 2006

Abstract

Protein lengths vary considerably from a few to thousands of amino acids and length variations are documented to have multiple effects. A computational approach to investigate the functional impact of protein length variation in genetic disorders is presented. The genes for huge proteins are found to have more introns. Our analysis also shows greater involvement of huge proteins in hereditary diseases.

Keywords: huge proteins, protein length, human, disease, OMIM