- Article -
| In Silico Biology 7 S1, 03 (2007); ©2007, Bioinformation Systems e.V. |
Integrating pathway data for systems pathology
Edgar Wingender1, 2 *, Jennifer Hogan1, Frank Schacherer1, Anatolij P. Potapov2 and Olga Kel-Margoulis1
Department of Biochemistry and Molecular Biology B, Faculty of Chemistry
University of Murcia, 30100 Murcia.
* Corresponding author
Email: edgar.wingender@biobase-international.com
Edited by I. Rojas and U. Wittig (guest editors); received and accepted March 21, 2007; published March 30, 2007
Abstract
The HumanPSD database on the complete proteomes of human, mouse and rat has been integrated with the databases TRANSFAC on gene regulation and TRANSPATH on signal transduction to provide a comprehensive systems biological platform for these organisms. As a next step, integration with PathoDB and PathoSign on pathologically relevant mutations is planned together with an extension beyond the limits of the individual cell, towards intercellular networks, by integrating the database EndoNet on hormonal networks as well. The overall aim is to come up with a platform that is suitable to provide knowledge for systems pathology, i. e. a system-wide modeling of pathological states and their development.
Keywords: proteome databases, HumanPSD, TRANSFAC, TRANSPATH, EndoNet, database integration, annotation strategy, systems pathology