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Volume 7

Reaction Kinetics

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In Silico Biology 7 S1, 10 (2007); ©2007, Bioinformation Systems e.V.  

Integration of CellDesigner and SABIO-RK

Akira Funahashi1,2,3,4*, Akiya Jouraku1,5, Yukiko Matsuoka1,4 and Hiroaki Kitano1,3,4,6

1 JST/ERATO-SORST Kitano Symbiotic Systems Project, Japan
2 School of Medicine, Keio University, Japan
3 School of Fundamental Science and Technology, Keio University, Japan
4 The Systems Biology Institute, Japan
5 School of Science for Open and Environmental Systems, Keio University, Japan
6 Sony Computer Science Laboratories, Inc., Japan

* Corresponding author

Edited by I. Rojas and U. Wittig (guest editors); received and accepted March 21, 2007; published March 00, 2007


Understanding the logic and dynamics of gene-regulatory and biochemical networks is a major challenge for systems biology. To facilitate this research topic, we have developed CellDesigner to visualize, model and simulate biochemical networks. CellDesigner allows the users to easily create networks using solidly defined and comprehensive graphical notation. CellDesigner utilizes SBML to described models and can simulate models using an integrated SBML ODE Solver or third party simulation engine; thus enabling users to simulate through a sophisticated graphical user interface. Although CellDesigner can integrate with existing databases (KEGG, PubMed, BioModels, etc.), by calling a web browser, or connecting to its web page through HTTP, integration with SABIO-RK has the potential to expand connectivity and semi-automate visualization and model building. SABIO-RK contains information about biochemical reactions, related kinetic equations and parameters. Also information about the experimental conditions under which these parameters were measured is stored. By using the Web service API provided by the SABIO-RK team, we have succeeded to directly connect to the database, send search queries by ID or name of its component, and then import the query results into CellDesigner.

Keywords: systems biology, SBML, SBGN, database integration, Web services, kinetic modeling, biochemical simulation