In Silico Biology



Topics to be covered by ISB (exemplary)

Organization of living systems:

Definition of molecular organization levels in living systems

Genomics:

Principles of genome organization revealed by computational methods
Relationship between genomic signals and biological functions
Genomic diversity of a species linked to certain phenotypes
Comparative genomics and genome evolution
Simulation of the function of gene networks

Proteins:

Secondary and tertiary structure prediction of proteins
Structure-function relationships of protein classes
Evaluation and prediction of protein-protein and protein-ligand interactions

Computer-aided discoveries in sequence and structure databases:

Modelling of biological reality in databases
Evaluation of sensitivity and selectivity of database searching methods
Novel protein and nucleic acid sequence and structural motifs associated with specific functions
Theory and practice of protein function prediction
Novel protein families and superfamily relationships uniting known families

Other topics:

Simulation of metabolic pathways
Pathological aberrations in regulatory networks

Linking experimental and theoretical approaches:

Evaluation of a set of new experimental data by computational tools